How do psychiatric drugs mimic the effects of neurotransmitters in order to t

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How do psychiatric drugs mimic the effects of neurotransmitters in order to treat psychological disorders?
How can the “fight-flight-freeze” response be helpful to humans in emergency situations? When may the “fight-flight-freeze” response be harmful, or non-beneficial? 
The amygdala and hippocampus are located in close physical proximity to one another in the brain. What significance or importance has this had on human evolution?

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