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1-The study and analysis of the role of inflammation and immune dysregulation in psychiatric conditions has a significant impact in the development of new therapeutic interventions in the treatment of these conditions (Köhler et al., 2020). The use of anti-inflammatory agents as adjunctive therapy in mental health disorders. For example, non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors have shown promise in reducing depressive symptoms when used in conjunction with traditional antidepressants (Köhler et al., 2020). Minocycline, another anti-inflammatory medication has also been studied for its potential benefits in the treatment of schizophrenia (Deakin et al., 2020). In other hands immunomodulatory therapies such as monoclonal antibodies have been used in treatment-resistant depression with some promised results (Deakin et al., 2020). These therapies are intended to reduce the inflammatory burden and improve psychiatric symptoms (Deakin et al., 2020).
2-Schizophrenia, a complex and severe psychiatric disorder, has also been associated with immune dysregulation. Studies indicate that individuals with schizophrenia often exhibit increased levels of inflammatory markers, such as IL-1β and IL-6. These inflammatory processes might contribute to the pathophysiology of schizophrenia by disrupting neural connectivity and impairing neurotransmission. Inflammatory cytokines can interfere with dopamine and glutamate pathways, which are crucial for cognitive and emotional regulation. This disruption can result in the hallucinations, delusions, and cognitive deficits characteristic of schizophrenia (Upthegrove, R., et Al.) (2020)
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