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ESSAY: Discuss the neural mechanisms involved in the
perception of pain.
General Comments on Essay Assignments
One of the objectives of this unit is to develop the ability
to read critically in the field.
Emphasis in the essay assignments should thus be on
criticism and evaluation of information, rather than on the supply of
information itself.
WORD COUNT: 4000 words (exclusive of any reference list) in the essay
assignment.
Point to discuss/ research:
– Peripheral Transduction of pain
– Transmission to the Spinal Cord
Spinal Processing and Modulation:
Neurotransmitters: Glutamate and substance P are the primary excitatory neurotransmitters involved in transmitting pain signals to second-order neurons.
Modulation: Endogenous opioids (e.g., endorphins, enkephalins) and other inhibitory neurotransmitters (e.g., GABA, glycine) can modulate pain signals, reducing the perception of pain.
*Gate control theory
Ascending Pain Pathways
Central processing
Descending Pain Modulation
Discuss peripheral and central sensitization + Neuroplasticity
Important to use research articles, the professor requires us to maintain a literature matrix of the research
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