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Structure of the review:
The review must have a title, an
abstract, an introduction, several chapters and an outlook/future perspective
section at the end.
Title:
must be informative and representing the content
Abstract
(15 % of total grade)
1-2 sentences background
information, then one or more sentence on what the reader can expect from this
review (most important issues). The last sentence should describe the impact of
this information on the field. The abstract is limited to < 150 words.
Introduction
(15 % of total grade)
Introduce the broader topic; make
clear to the reader why the information/chapters you will discuss are of
importance.
Chapters
(60 % of total grade)
Each chapter deals with one aspect
of the review topic; usually reviews have 2-4 chapters. In each chapter
relevant results are described, discussed and placed in a logical
connection/context. You should put the results from the different papers in a
logical context and explain how they complement (or contradict?) each other.
The experimental approach for each result can be mentioned briefly (“by using
xx technique”), however it can be discussed more in depth if results are not
consistent with each other. You should also mention open questions and lacking
knowledge, if possible, with the approach that could be used to address the
question.
Do not forget that each
statement/finding in your review should be supported by a citation! Concerning
citation format, you can choose between citing with numbers or using first
author name plus et al., but be sure you use a consistent format
throughout your review.
Outlook
/future perspectives (10 % of total grade)
This final part of the review sums
up the most important outcome from the chapters and then gives a broad-scale
outlook on the future. Which developments are to be expected? What can the
reader expect from this field within the next years?
Throughout the whole review please
pay attention to correct terminology.
Aims:
Overview
of recent advances in molecular disease research based on protein
structure.
Insight
into the relation between protein structure/(mal-) function.
Insight
into the relation protein (mal-) function/disease.
TOPIC: Energy Metabolism as the
Target of Antibiotics in Tuberculosis
Content:
Important
aspects that should be part of your review are:
Which
medical problem is studied and which proteins are involved?
What is
already known about structure and function of these proteins? This must be a
central point in your report/presentation.
What is
not known yet? What information is missing?
How
could you use (already existing and/or future) insight in structure and
function of these proteins to solve or prevent the medical problem?
suggest the following structure:
1. Short introduction of medical need for combating TB, ending with energy metabolism as promising target pathway
2. General overview of how the ETC in Mtb works
3. ATP synthase and BDQ
4. Menaquinone biosynthesis as target
5. Cytochrome bd function and role as target
6. Outlook
For each target enzyme explain the enzymatic function and say what is known concerning structure, are inhibitors known (clear how they act?) and what is not known.
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