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As we move into Module 3, we will bee looking into different types of epistatic interactions and we will see some examples in plants as well as in chickens and dogs. Epistatic interactions are also studied not only to explain the why or how we observed different phenotypes but also in order in the context of evaluating resistance to infections. An article published in Nature by Desrosiers et al. in 2005 studied how epistasis between the mouse Klra and the major histocompatibility complex class I loci is associated with resistance to mouse cytomegalovirus (MCMV) infection. The research group found through a series of experiments that this is due to a new natural killer cell mechanism implicated in MCMV resistance, which depends on the functional interaction of the Ly49P receptor and the major histocompatibility complex class I molecule H-2Dk on MCMV-infected cells.
For this week, find a scientific article that provides an example of epistasis in an organism of your choice. Remember to tell us why you chose the article and to comment on at least two other posts by your peers.
https://www.nature.com/articles/ng156435Clicks: Justine Moriarty, Stephanie Godinez, Jake Sheaffer, Joseph Jiang, Elizabeth Miller, Shuo Cui, Calvin Martin, Jamie Festa, Rachel Glover, Nathan Fredenburg, Jan Valle Cruz, Preet Kaur, Travis Marshall, Kiowa Beardsley, Casey Bustamante, Jugnu Ahluwalia, Caren Meckelnburg, Angelica Hernandez, Inez Billy, Adelena Purvis, Brian White, Tegan Homol, Brandon Pruitt, Alexus Williams, Naomi White, Lizzy Mathe, Kendall Lee, Anahi Delgado, Brianna Parker, Elizabeth Finley, Jasmine Truong, Carla Marcia, Sareena Leyba, Michael Brozycki, Dale Donecker
NATURE – May 14, 2005
Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell–mediated innate resistance to cytomegalovirus infection – Nature GeneticsNature Genetics – Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell–mediated innate resistance to…
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